Main
Events
The current projects cover the following objects of study
Importin alpha and its complexes
Aim: to study the molecular and mechanistic details of nucleo-cytoplasmic trafficking.
Plasmodium falciparum CTP: cytidylyltransferase
Aim: to understand species-specific inhibition allowing drug design.
Staphylococcus aureus phage dUTPase and promoter regulatory element Stl1
Aim: to provide insight into regulation of pathogenicity island gene expression.
Mycobacterium tuberculosis dUTPase
Aim: species-specifc drug design.
Human dUTPase
Aim: to understand uracil-DNS metabolism in humans.
Drosophila uracil-DNA degrading factor
Aim: to understand the role of uracil-substituted DNA in metamorphosis.
RNA silencing supressor P1
Aim: Structural studies of the viral RNA silencing suppressor P1: Molecular determinants of Argonaute target cleavage inhibition